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Question 3: What safeguards are there co ensure che long-cerm safety of
alos On 3s
newly released pesticides?

A new peseicide would have to pass a screening tese for carcinogentectty.

=.a. Amies cest - on gutagenicity in bacterta, or Karyocyping which
uses nuclear changes in human whice 5Lood cells,

Tt would chen be fed co case animals, e.g, rats, co determine tts
LD.50. The dose ac which 50% of che tese animals die. Thia 43 a measure

of acute toxicity.

Chronic toxicity {s neasured by feeding the animal che maximal dose
which dees noc kill che animal for 1/2 its life span. This ts done on two
generaCions of the animal in scrains especially suscepcible to various
cancers. This gives a measure of carcinogenicity, effects on repraduccion
and Ceracogenicicy,

Question § Are thesa tests adequate?

No teste on animals {s adequate to access the hazard tc humans. However,
the tescs currencly used are much Cougher than they were a few years ago,
and are the bese we can do shore of human experimencacion.

Question 7: What is the shore and tong-cerm safecy of vesticides?
Acute toxicity can be judged from che O50,

The following {3 a table of pusticides used and cheir LDSO’s,

These doses ware obtained from animal scudies, and accicenral averdoses.
*e zurresponding dose for a baby could te 1/20 of this amount, and for 3
chiad of 10 vears about 1/2 of chigs amount,

The concentrates of saveral of the pesticides used are hazardous.

The diluce products as used in che sprayer (usual concentration 0.1%)
pose a very small and accepcable hazard.

The long-cerm effects of some of the pesticides guch as 240 have been
well documented after many years of large scale usage, and their safety
can be affirmed,

Te should be neced char MD, unlike ics fellow chlorphenery compound,
“457, cannoc itn sheory, and does noc in practice concain Dioxans as bvoroducts,
It does noc, therefore, have the same pocential for Ceratogentcity chac
245T does.

Other newer pesticides, such as Roundup (Glyphosace), have noe been
used for suffictencly long to allow a doygmacic assertion of {23 long-cerm
safety.

veel

EE casei! MPR TLS oP NESE os KET