-~13-

5) Casaron (dichlobenil):

In her Summary of Findings in Literature Reviews of Four Selected
Herbicides: 2,4-D, Dichlobenil, Diquat & Endothall, for the

City of Seattle, Metro Seattle, the University of Washington,

and the Washington State Department of Ecology, January 1980
(Attachment 7), Dr. Ruth Shearer states:

"Toxicological testing of dichlobenil (Casaron) has been
extremely limited. Carcinogenic tests have been inadequate
and there has been no testing of developmental or genetic
effects in animals. One study indicates that dichlobenil
inhibits the growth of young rats and decreases fertility.
Some of its breakdown products are known to be highly toxic
to energy metabolism. The only reported acute effect in
humans has been chloracne, a severe skin condition....

Dichlobenil is also rapidly absorbed through the skin, lungs
and gastrointestinal tract. It is metabolized into a variety
of known and unknown products, some of which are highly toxic
to the energy metabolism of the body. Dichlobenil testing
for developmental toxicity, mutagenicity and carcinogenicity
are so inadequate that no conclusions are justified. One
adequate study indicated an inhibition of young rat grown

and decrease in fertility."

6) Ureabor (sodium metaborate tetrahydrate, sodium chlorate, Bromacil);:

Not very much information appears available at the moment on
Ureabor, except that one of its components is Bromacil,
and another, sodium cnivorate , also known as Attacide, is

on the American and Canadian I.B.T. Lists.

7) Embark (mefluidide):

Embark contains the compound mefluidide, currently on the
American and Canadian I.3.7. Lists of chemicals that might

have been improperly or insufficiently tested by I.B.T. Laboratories,
Reference sources used had only this information available.

7) Atrazine (Primatol A, A-Atrex), soil sterilizer:

Dr. Shearer reports that the Registry of Toxic Effects of
Chemical Substances, published annually by the National Institute
of Safety and Health, a U.S. government agency, cites severe

eye irritation in tests with Atrazine (Primatol A).

In addition, the Italian Review records mutation tests indicating
a mutagen metabolite, Causing unscheduled DNA synthesis in

human cell cultures, "a measure of DNA damage." Dr. Shearer
states this is a "strong indication (the agent) might cause
cancer or mutations,"