Wednesday, November 16, 1988 THE REVIEW 9781-2nd St., Sidney B.C. If the risk of coronary lesions in humans can be reduced by increas- ing dietary omega-3 fatty acids, ~ why is it that fish which have naturally high levels of the fatty _acids themselves have coronary lesions? _.. “By the time salmonids mature, they have high levels of very severe coronary lesions,’’says Tony | Farrell, a professor in the depart- ment of biology at Simon Fraser University. — Farrell and his colleague, Richard Saunders of the federal Department of Fisheries and Oceans in New Brunswick, are investigating coronary lesions in three salmonids: Atlantic salmon, - Pacific salmon, and B.C. steelhead - ~ trout. “Lesions are abnormal out- growths of vascular smooth mus- cle into the lining of an artery,”’says Farrell, “‘In saimo- nids, lesions may be responses to vascular injury brought about by the stresses of natural activities, such as. migrating, predatory behavior, or avoiding predators. “These activities all cause high excursions in blood pressure which can. deform the coronary artery and cause injury.” ~_ Jn mammals, damage to vessel walls leads to the release of growth factors from damaged.cells or . adhering blood cells, as in blood clotting. This stimulates the . growth of vascular smooth muscle ‘and can lead to the deposition of - lipids from the blood. It is these lipid depositions -which reduce the flow of blood or block ‘the artery, leading to heart ‘attacks. Omega-3 ‘fatty acids are. * Believed to lower: blood. triglycer. | ide levels. by. slowing clotting --. “times and inhibiting. the growth - =: factors: which stimulate vascular - _- smooth muscle division. “Since fish lesions do not con- tain the lipid deposits found in. ~~. mammalian lesions, it is possible -that the high omcga- -3 fatty acid... | “levels in-fish prevent the formation - oN OOF: lipid. Genesis in vid lesions,” = o Says: Farrell. : : “It is also possible that iésion ce formation in'fish has a completely { “ different cause; and: that omega-3 we! fatty acids are inconsequential. Wee: ove. Lesions “in Atlantic: ‘salmon. : a? ee gh 4 have a’ fairly. strict ‘relationship att ~-> with growth. The’ bigger the fish; [Uh{ 7 “the more. lesions they’ haves. and ff ‘ Funeral Chapels | - 656-2932 or 388-5155. f Offer a complete choice of 7 Professional Services. _ = TRADITIONAL ~ = MEMORIAL — DIRECT CREMATION — FULL __ PRE-ARRANGEMENT SERVICES | Services from your church or . in either of our chapels at 1803 QUADRA STREET | “VICTORIA KEN THEAKER: <-.»Funeral Director, 0 - “Ityou'ro os | | i IN. “TOWN “and don’ t know which way to turn, eal theo You'll be e glad you did, 7 . ‘nostosses ati - Cloudia Parfit 656-7608 oe & Contra! Saanich): Bov Blgant 652-5452 Vicky dackson 652- Sony Wolaine Wagon Anawaring © “Boning 4 478: fies ; faster-growing fish accumulate lesions faster.” There is a major difference between Atlantic and Pacific sal- ' mon — Pacific salmon generally spawn only once before they die, and lesion severity peaks just © before death. Atlantic salmon. and steelhead trout are repeat spawners and records show some individuals have migrated and spawned as many as six times. _ “This could indicate that lesions in the Atlantic salmon and the rally,” says Farrell. “‘Such a finding would have tremendous medical significance.” Recent discoveries teve shown that lesions can continue to accu- mulate in cultured Atlantic salmon after spawning. ‘‘We are beginning to suspect that repeat spawners may have a “low lesion incidence at first spawning, "says Farrell. “We are now extending our work to sam- _ ples of wild steclhead trout to check out this possibility.” How do coronary lesions in humans? “We simply don’t know,’’says Farrell, “but we are investigating a lot of possibilities.” Farrell points out that while fish consumption can increase omega- 3 fatty acids, thereby reducing cardiovascular risk profiles in humans, not all fish are equally rich in this beneficial factor... ~ “vr ike terrestrial life, freshwater life predominantly use omega-6 fatty acids as biological building blocks and fuel. Marine life use ~ source of omega-3 fatty acids than freshwater fish.” But not all marine fish have the same amounts of omega-3 fatty acids. “More active fish such as tuna, salmon or anchovies, store liquids in their red muscle for fuel,”’says Farrell. : “Less active marine fish, such as the ling cod or flounder, store lesser amounts of omega-3 fatty acids. “There are exceptions however. Page B20 by aquaculture and food pellets used in these operations are usually enriched with marine lip- ids. “This means cultured fre- . shwater trout can have omega-3 levels similar to marine fish, and much higher than ‘wild’ fre- shwater. trout.” Farrell’s research has been funded by grants from the B.C. 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